Changes to the skin can be a sign that something is wrong. Rashes, hives, and itching may signal an allergic reaction, a bacterial skin infection, a viral infection, or an autoimmune disease. A mole may be a sign of skin cancer.
The American Academy of Dermatology recommends checking any moles for the ABCDEs of skin cancer: A = asymmetry, B = border (irregular or poorly defined), C = color (that varies from one area to another), D = diameter (greater than 6mm or the size of a pencil eraser), and E = evolving (a mole or lesion that changes in size, shape, or color). If you notice any of these warning signs, see a doctor.